← Research library / Skin and tissue
GHK is a three amino acid sequence that binds copper with high affinity. It occurs naturally, is present in plasma at meaningful levels in youth, and declines substantially with age. That decline is the entire basis for the anti-aging positioning.
The topical literature is the strongest part of this compound's case. Controlled studies in cosmetic dermatology have reported improvements in skin density, fine lines and wound healing. That work is real and it is why copper peptides appear in mainstream skincare.
Injectable use is a different question entirely, and the evidence base for it is not the same evidence base. Almost every claim you will see for injectable GHK-Cu is borrowed from topical or in vitro work. When a seller cites skin studies to justify an injection, that is the move to watch for.
Copper accumulation is the concern that gets skipped. Chronic excess copper is associated with oxidative stress and, at extremes, hepatic effects. Anyone with Wilson's disease or a copper metabolism disorder should not go near this. Repeated high dose injection is not the same risk profile as a face cream and should not be discussed as though it were.
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Regulatory status current as of the page date. This area is changing quickly and this page is reviewed monthly. [set review reminder]